Richard M O'Brien Selected Research

Glucose-6-Phosphatase (Glucose 6 Phosphatase)

11/2011	Deletion of the G6pc2 gene encoding the islet-specific glucose-6-phosphatase catalytic subunit-related protein does not affect the progression or incidence of type 1 diabetes in NOD/ShiLtJ mice.
11/2008	Foxa2 and MafA regulate islet-specific glucose-6-phosphatase catalytic subunit-related protein gene expression.
1/2008	Long-range enhancers are required to maintain expression of the autoantigen islet-specific glucose-6-phosphatase catalytic subunit-related protein in adult mouse islets in vivo.
12/2006	Deletion of the gene encoding the ubiquitously expressed glucose-6-phosphatase catalytic subunit-related protein (UGRP)/glucose-6-phosphatase catalytic subunit-beta results in lowered plasma cholesterol and elevated glucagon.
12/2005	The glucose-6-phosphatase catalytic subunit gene promoter contains both positive and negative glucocorticoid response elements.

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Richard M O'Brien Research Topics

Disease

6	Type 2 Diabetes Mellitus (MODY) 01/2022 - 07/2009
5	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 11/2011 - 07/2004
3	Glycogen Storage Disease (Glycogenosis) 01/2022 - 12/2006
2	Hypoglycemia (Reactive Hypoglycemia) 11/2020 - 12/2006
2	Hepatocellular Carcinoma (Hepatoma) 01/2009 - 12/2005
1	Metabolic Diseases (Metabolic Disease) 01/2022
1	Obesity 01/2020
1	Glucose Intolerance 01/2020
1	Hemolytic Anemia 01/2020
1	Body Weight (Weight, Body) 01/2017
1	Hyperinsulinism (Hyperinsulinemia) 01/2017
1	Insulin Resistance 05/2013
1	Hypercholesterolemia 12/2006
1	Hypertriglyceridemia 12/2006
1	Neoplasms (Cancer) 07/2004
1	Insulinoma 07/2004

Drug/Important Bio-Agent (IBA)

5	Blood Glucose (Blood Sugar)IBA 01/2022 - 05/2013
5	Glucose-6-Phosphatase (Glucose 6 Phosphatase)IBA 11/2011 - 12/2005
3	Proteins (Proteins, Gene)FDA Link 11/2011 - 01/2008
3	AutoantigensIBA 11/2008 - 07/2004
2	Insulin (Novolin)FDA Link 01/2020 - 01/2017
2	Glucose (Dextrose)FDA LinkGeneric 01/2020 - 05/2013
2	Amino Acids FDA Link 01/2016 - 07/2009
1	EnzymesIBA 01/2022
1	Phosphoric Monoester Hydrolases (Phosphatases)IBA 01/2022
1	Nonesterified Fatty Acids (NEFA)IBA 01/2017
1	CholesterolIBA 01/2017
1	Glucagon (Glukagon)FDA Link 01/2017
1	zinc-binding protein (zinc binding protein)IBA 12/2016
1	ZincIBA 12/2011
1	AutoantibodiesIBA 07/2009
1	EpitopesIBA 07/2009
1	Epidermal Growth Factor (EGF)IBA 01/2009
1	Transcription Factors (Transcription Factor)IBA 11/2008
1	Liver GlycogenIBA 12/2006
1	GlucocorticoidsIBA 12/2005
1	Chloramphenicol O-Acetyltransferase (Chloramphenicol Acetyltransferase)IBA 07/2004

Therapy/Procedure

1	Ketogenic Diet 11/2020